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Publication: Watchon et al., 2021 - Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo
All Figures: Figures for Watchon et al., 2021

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Fig. 2

Sodium valproate treatment increased acetylated histones in HEK293 cells expressing human ataxin-3. A HEK293 cells expressing human ataxin-3 were treated with either sodium valproate (Valproate) or vehicle and protein lysates extracted from groups of larvae underwent immunoblot analysis for acetylated histones 3 and 4 and human ataxin-3. Quantification revealed that valproate treatment increased the amount of B acetylated histone 3 (ac-H3K9); C acetylated histone 4 (ac-H4K5); and D expressed human ataxin-3, compared to vehicle control treatment (*p = 0.023, ***p = 0.0007, ***p = 0.0001 respectively; n = 4–5 independent experiments). Data represents mean ± SEM and statistical analyses used were unpaired student t-tests

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