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Figure 8
Induction of miR-21 in human islets leads to a dedifferentiated phenotype and reduced expression of mRNAs regulating ?-cell identity. (A) miR-21 levels were increased in human islets transduced with the miR-21 virus as compared to human islets transduced with scramble virus (B) Levels of ALDH1A3 are increased in miR-21 induced human islets. (C) mRNA expression of PDX1, along with TGFB2 and SMAD2 was significantly decreased in human islets transduced with the miR-21 lentivirus. n = 6; ?p < 0.05.
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