ZFIN Image: Gao et al., 2021, FIGURE 1

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Figure Caption

FIGURE 1

CBE synergisti cally inhibited the growth of BEL-7402 cells. (A) The chemical structure of BER and EVO. (B) Dose-response curves of BER, EVO, and CBE in BEL-7402 cells. Cells were treated with BER, EVO, or CBE for 48 h. To prepare CBE, a constant ratio (BER/EVO = 10:1) was used, and the curve was plotted against BER concentration. Cell viability was determined by MTT assay. (C) Isobologram for CBE at the dose ratio of 10:1. The red line represents the intercept line of the IC50 values for BER or EVO alone, and the “×” indicates the IC50 value for CBE at the dose ratio of 10:1. CI < 1, CI = 1, and CI > 1 indicate synergism, an additive effect, and antagonism, respectively. (D) The Venn plot of DEGs under the treatments of BER, EVO, and CBE.

Acknowledgments

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