Figure 6.

Figure 6.

SIRT3 activation by RSV enhances antimicrobial responses and ameliorates mitochondrial oxidative stress during Mabc-R infection. (a and b) SIRT3 WT and KO mice (n = 4 each group) were infected with Mabc-R (1 × 10⁶ CFU), followed by treatment with or without RSV (50 mg/kg), and monitored at 7 dpi. (a) Data are shown as log pulmonary CFUs. (b) The lung tissues of the mice were subjected to qRT-PCR analysis. (c) MitoSOX Red staining for Mabc-infected WT BMDMs in the presence or absence of RSV (20 µM). Left, representative images; right, quantitative analysis. Scale bar, 50 μm. *P < 0.05, **P < 0.01, ***P < 0.001. Non-parametric test (a and b; c right); Data represent three independent experiments (c left), and values represent means (± SEM) from three or four independent experiments performed in triplicate (a, b, and c right).