Figure 2

Figure 2

Simulation of zper1b:luc expression dynamics under various lighting conditions. (A) On this plate, cell cultures were exposed to 6 days of constant darkness, three 12:12 LD cycles, and 3 days of constant light. This recording was used to estimate the model parameters. (B) On this plate, cell cultures were exposed to a combination of LD cycles, constant darkness, and constant light. The same parameters as in (A) were used to run the model, showing that the model can also reproduce dynamics of data not used for parameter fitting. (C) This plate was exposed to 15:15 LD cycles. Parameters estimated from (A) were used without further fitting. (D) This plate was exposed to 10:10 LD cycles. Parameters estimated from (A) were used without further fitting. (E) Simulated phase response curve to 12-h light pulses.