ZFIN Image: Li et al., 2021, Figure 9

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Figure 9

In vivo anti-tumor effects of casearlucin A in zebrafish xenografts. CM-DiI stained HepG2 cells were transplanted into 2 dpf zebrafish embryos by microinjecting. 4 h later, tumor-bearing embryos were treated with casearlucin A (5, 10, and 20 μM) and etoposide (10 μM) for 48 h (n = 15/group). DMSO was used as a negative control. (A)Intensity and distribution of the red fluorescence were imaged under a confocal microscope. (B) Fluorescence intensity of the tumor xenografts, representing the number of HepG2 cells. (C) Quantification of the fluorescent area of the tumor xenografts, representing HepG2 cell metastasis. Results are expressed as means ± SD. **p < 0.01 and ***p < 0.001 versus control group.

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