ZFIN Image: Follain et al., 2021, Figure 2

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Figure Caption

Figure 2

Inhibition of VEGFRs with sunitinib impairs endothelial remodeling in vitro. (A) Immuno-labelling pictures showing the presence of KDR (white) at the site of endothelial remodeling (Assessed with PECAM enrichment (green) around tumor cell (red)). Z-projections and two z-projection from side and top view are shown. (B) Experimental setup: microfluidic channel for endothelial remodeling assay. (C) Representative images of all steps: 1-No transmigration, 2-Transmigration without remodeling evidence, 3-Transmigration with remodeling. Quantification of the normalized number of transmigrating cells and remodeling activity. (D) Phenotypic distribution of CTCs attached to endothelial layers exposed to flow and treated with vehicle or sunitinib. N: flow/vehicle = 88, flow/sunitinib = 150, Fischer test.

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