ZFIN Image: Zhang et al., 2021, Figure 6

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Figure Caption

Figure 6

Cardiac mechanics analysis of developing zebrafish heart. (A–D) Volume change of developing zebrafish heart was measured by U-net-based autosegmentation, showing consistent increase in volume in both the atrium and ventricle. (E,F) After notable morphology change after cardiac looping, end-diastolic volume (EDV) and end-systolic volume (ESV) were increased significantly in both the atrium and ventricle. At 5 dpf, ESV was also significantly increased compared to 4 dpf. (G) While SV of the ventricle showed an increasing trend, that if the atrium remained at a similar level from 2 to 5 dpf. (H) Ejection fraction (EF) analysis demonstrated a decreasing trend from high EF at 2 dpf. *p ≤ 0.05.

Acknowledgments

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