ZFIN Image: Miserocchi et al., 2021, Figure 4

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Figure Caption

Figure 4

3D cultured cells acquire drug-resistance mechanisms. (A, B) Cytotoxicity analysis of UM-SCC6 and UPCI:SCC090 cell lines treated with cisplatin, 5-fluorouracil, cetuximab, and gemcitabine. Differences between 2D and 3D cultures were assessed by a 2-tailed Student’s t-test and accepted as significant (*) at P < 0.05. (C, D) NT5E, FOXM1, FLT1, and ABCA3 gene expression analysis in 3D vs. 2D cultures after 24, 48, and 72 h. Data represent mean ± standard deviation. *P < 0.05, 2-tailed Student’s t-test. 3D, 3-dimensional; CIS, cisplatin; 5-FU, 5-fluorouracil; CETU, cetuximab; GEM, gemcitabine; 2D, 2-dimensional.

Acknowledgments

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