ZFIN Image: Meserve et al., 2021, Fig 5

Image

Figure Caption

Fig 5 Kv1.1 functions outside the Mauthner command neuron to control swim movement magnitude.

(A-D) kcna1a mutants expressing Tol056 (GFP in Mauthner cells; green), 62a:Gal4 (Mauthner specific) and UAS:NTR-RFP (magenta). 62a>NTR-RFP is mosaic so some fish do not display expression in Mauthner cells (A) while others do (B). Before treatment with metronidazole (Mtz) at 4 dpf, all fish have GFP+ Mauthner cells (A,B). After 24 hr Mtz treatment, Mauthner cells are present in fish without initial NTR-RFP Mauthner expression (C) and absent in fish that displayed initial Mauthner NTR-RFP expression (D). (E-H) Kinematic parameters of the acoustic startle response in kcna1a sibling and mutant larvae with or without NTR-RFP expression in Mauthners and with or without Mtz treatment. Each point is the average response over ten trials for an individual larva. n≥9 larvae, **p<0.0001 (one-way ANOVA with Tukey correction for multiple comparisons). Scale bars = 50 μM.

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Acknowledgments

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