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Figure 5—figure supplement 1—source data 1. Atglistatin, Auranofin, and JS-K in vivo dose titration.

Viability of 21 days post-fertilization (dpf) Tg(-3.5ubb:plin2-tdTomato) zebrafish was measured after 24 hr of treatment with dimethyl sulfoxide (DMSO) or increasing concentrations of (A) Atglistatin, (B) Auranofin, or (C) JS-K. Percent larval viability measured from N = 3 independent experiments. After 24 hr of drug treatment, 21 dpf zebrafish were imaged to measure (D) area, (E) standard length, and (F) area/standard length. Data points indicate individual fish for N = 5 independent experiments; DMSO n = 29; 1 µM n = 32; 10 µM n = 28; 40 µM n = 31. Bars indicate mean and SEM. Significance calculated via Kruskal-Wallis with Dunn’s multiple comparisons test; *p<0.05.

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