ZFIN Image: Li et al., 2021, FIGURE 6

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Figure Caption

FIGURE 6

Perturbation of the Papp-aa-Igfbp-a-IGF signaling loop rescues the body edema and premature death in stc1a^{– /–} fish. (A,C) Gross morphology of fish of the indicated genotypes at the indicated stages. Lateral views with anterior to the left and dorsal up. Scale bar = 0.5 mm. (B,D) Survival curves. Embryos were raised in E3 embryo medium. Dead embryos were collected daily and genotyped individually. The survival curves of indicated genotypes and the total fish numbers are shown. P < 0.0001 by log-rank test. (E–J) Progeny of stc1a (+ 17)^+/– intercrosses were raised in E3 embryo media containing DMSO (E,F), 0.3 μM BMS-754807 (G,H) or 5 μM Rapamycin (I,J) starting from 3 dpf until the indicated time. Representative morphological views of the indicated genotypes at the indicated stages are shown in (E,G,I). Scale bar = 0.5 mm. P < 0.0001 by log-rank test. Dead fish were collected daily and genotyped individually. The survival curves of the indicated genotypes and the total fish numbers are shown in (F,H,J).

Figure Data

Phenotype details

Acknowledgments

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