Figure 2 Physicochemical properties of poly(lactic-co-glycolic acid)-pterostilbene (PLGA-PTE). (A) HPLC chromatogram of PLGA-PTE (B) Transmission electron microscopy analysis revealed that all of the synthesized PLGA-PTE was spherical in shape (scale bar = 500 nm). (C) The mean hydrodynamic size of PLGA-PTE determined by dynamic light scattering (DLS) is 56.9 ± 13.6 nm and the polydispersity index (PI) is 0.155. The following figures are the UV-Vis absorption spectra of (D) PTE, (E) PLGA, and (F) PLGA-PTE. Comparison of the visible light absorption spectrum of UV light confirmed that PLGA-PTE was successfully synthesized. (G) The cumulative drug release of PTE from PLGA NPs formulation at different time points was detected by UV-Vis spectrophotometer at 310 nm. Triangle symbol indicated the PTE concentration released in water. The data are presented as the mean ± standard deviation of three independent experiments.* p < 0.05 compared with 0 h groups.
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