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Figure 3 Effects of vandetanib (VAN) and cabozantinib (CAB) on apoptosis in medullary thyroid carcinoma (MTC) cell lines. Cell death analysis after six days of incubation with VAN and CAB in TT (a–c) and MZ-CRC-1 cell lines (d–f) through flow cytometry with Annexin V and propidium iodine. The proportions of cells in early apoptosis (a,d), late apoptosis (b,e) and necrosis (c,f) were expressed as the percentage compared with the untreated control (CTR) and represent the mean ± S.E.M. of at least three independent experiments. * p < 0.05; ** p < 0.01; *** p < 0.001.
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