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Fig. 4 Cardiac dysfunction was involved in hyperglycemic zebrafish. (a) Streptozocin (STZ) treatment induces enlarged heart in zebrafish, which is partially canceled by A769662, adenosine monophosphate‐activated protein kinase activator; scale bar, 0.5 mm. (b) Typical electrocardiogram diagram; (i) normal electrocardiogram; (ii) escape rhythm representative diagram; (iii) T‐wave inversion; and (iv) “voltage alternation” diagram. (c) Electrocardiogram parameters were significantly different in the two groups, such as heart rate, PR interval, QRS interval, QTc interval, ST‐T change and voltage‐alterative. (d) Typical B‐mode echocardiography images of hyperglycemic zebrafish, control zebrafish and A769662 intervention zebrafish to evaluate ventricular morphology and function. Image data were automatically generated using the Vevo 2100 Workstation Software package (VisualSonics, Toronto, Canada). (n = 21 fish). *P < 0.05, **P < 0.01 compared with the wild‐type group.