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Fig. 1 Streptozocin (STZ) induces hyperglycemia in zebrafish. (a) Blood glucose assay analysis of blood glucose in vivo continues for 30 days. The fish were injected with STZ in a dose of 350 mg/kg and maintained in different days. Values >200 mg/dL were considered hyperglycemic. (b) Quantitative polymerase chain reaction analysis of glucose transporter (GLUT)1, GLUT2 and GLUT12 in hyperglycemic zebrafish hearts. Glyceraldehyde 3‐phosphate dehydrogenase (GAPDH) was measured as the control. (c) Western blot analysis of GLUT1, GLUT2 and GLUT12 in hyperglycemic zebrafish injected with STZ. GAPDH was used as the control. (d) Survival analysis of the hyperglycemic fish and control fish in 30 days. (e) Body mass analysis of the hyperglycemia zebrafish model. Each experiment was repeated a minimum of three times. **Highly significant difference (P < 0.01) in a two‐tailed Student’s t‐test.