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FIGURE 9 Modulation of inflammatory mediator (HMGB1, TLR4, NF-?B, TNF-?), transcription factor (CREB-1) and neuropeptide (NPY). The graph plot is represented as a fold changes in mRNA expression of HMGB1 (A), TLR4 (B), NF-?B (C), TNF-? (D), CREB-1 (E) and NPY (F). Data are represented as mean ± SEM, n = 6, and statistically analyzed by one-way ANOVA followed by Sidak?s multiple comparison test. &&&p < 0.001 and &p < 0.05 represents the significance level when second hit PTZ group is compared with VC group. ***p < 0.001 and *p < 0.05 represents the significance level when second hit PTZ group is compared with Pilo group. ###p < 0.001 and ##p < 0.01 represents the significance level when second hit PTZ group is compared with PTZ group. $$$p < 0.001, $$p < 0.01 and $p < 0.05 represent the significance level when DZP, mAb 1, mAb 2.5, and mAb 5 treated groups is compared with second hit PTZ group.