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Figure 10
Summary of neutrophil and macrophage responses to copper-induced damage in the larval olfactory organ (OO). The blood vasculature (BV, green) wraps the olfactory organ (gray) and the lymphatic vasculature (LV, red) extends along the ventral posterior aspect. In untreated animals (before copper), there are local neutrophils (blue) and macrophages (pink) associated with the OO. In response to damage (after copper exposure) of the olfactory sensory neurons (OSNs, dark gray), non-local neutrophils and macrophages migrated to the OO. Neutrophils migrated in association with the BV, and both neutrophils and macrophages were seen associated with the LV. Macrophages changed to a more rounded morphology as they engulfed debris of dying OSNs.