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Figure 3—figure supplement 1.

ID: ZDB-IMAGE-210204-88
Publication: Parab et al., 2021 - Endothelial cell type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain
All Figures: Figures for Parab et al., 2021

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Figure Caption

Figure 3—figure supplement 1. Developmental relationships between FGPs and mCP vasculature in WT, <italic>vegfab-/-</italic>, and <italic>vegfc-/-;vegfd-/-</italic> larvae.

(A–C") Dorsal views of 120 hpf WT (A–A"), vegfab^-/- (B–B"), and vegfc^-/-;vegfd^-/- (C–C") heads of larvae that carried the Tg(kdrl:EGFP) (A–C) and Tg(lyve1:DsRed) (A’–C’) transgenes (merged images shown in A"–C"). All of the vegfab^-/- larvae that lacked the DLV (n = 7) formed FGPs in the dorsal surfaces of the brain meninges (B–B"), as observed in WT larvae (n = 13). In contrast, vegfc^-/-;vegfd^-/- larvae (C–C") that exhibited the complete loss of FGPs (n = 9) formed the DLV and PCeV, as observed in WT fish. Yellow arrows point to the DLV and white arrows to the FGPs. Scale bar: 50 µm.

Acknowledgments

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