ZFIN Image: Dries et al., 2021, Figure 7

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Figure Caption

Figure 7

The function of Ncam1b during posterior lateral line development. (A) Expression patterns of Ncam1b, Fgfr1a, Wnt, Erm and Lef1 in the pLLS primordium. (B) Interaction of Ncam1b with Fgfr1a results in activation of the transcription factor Erm, which is involved in cell proliferation in the Trailing-Zone of PrimI. The Ncam1b/Fgfr1a interaction also initiates the expression of the chemokine receptor Cxcr7b, which is necessary for directional migration of the PrimI and for proneuromast deposition. Wnt signaling controls proliferation in the Leading-Zone via Lef1. In addition, it triggers Fgf signaling in the Trailing-Zone, which initiates apical constriction during formation of proneuromasts. Proneuromasts are stabilized by homophilic Ncam1b binding in trans. (Data related ① to Lecaudey et al. (2008) ② Aman et al. (2011) ③ Aman and Piotrowski (2008).

Acknowledgments

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