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Helal et al., 2021 - Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model

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Figure 5

Expression of selected cytokine mRNAs in hepatocytes and cholangiocytes of the liver in adult zebrafish. (A) Expression of selected cytokine mRNAs in cholangiocytes upon kras induction in hepatocytes. (B, C) Expression of il17a/f1 (B) and il17ra1a mRNAs in cholangiocytes and hepatocytes in WT and kras+ larvae following Dox induction from 3 to 8 dpf. (D) Expression of il17a/f1 mRNA in kras + and WT larvae treated with TCA and JTE-013 together with Dox from 3 to 8 dpf. In (A), gene expression values in the kras groups were normalized to their WT counterparts. In (B–D), all values were normalized to WT hepatocyte value. (E, F) Representative images of il17a/f1 downstream maker p-ERK staining (E) and quantification of pERK stained cells (F) in kras+ and WT zebrafish larvae treated with TCA and JTE-013 from 3 to 8 dpf. N = 10 per group. Scale bars, 20 μm Statistical significance: *P˂0.05.

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