Gene
il17a/f1
- ID
- ZDB-GENE-061031-3
- Name
- interleukin 17a/f1
- Symbol
- il17a/f1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity. Predicted to act upstream of or within inflammatory response. Predicted to be located in extracellular space. Is expressed in cholangiocyte; gill; and intestine. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17F (interleukin 17F).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Helal et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-il17a/f1 | N/A | Helal et al., 2021 |
| MO2-il17a/f1 | N/A | Helal et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | Interleukin-17, chordata | Interleukin-17 family |
|---|---|---|---|---|
|
UniProtKB:Q5TKT4
|
153 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
il17a/f1-201
(1)
|
Ensembl | 875 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-176M20 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001020787 (1) | 462 nt | ||
| Genomic | GenBank:BX294375 (1) | 188455 nt | ||
| Polypeptide | UniProtKB:Q5TKT4 (1) | 153 aa |
No data available
- Rawling, M., Schiavone, M., Mugnier, A., Leclercq, E., Merrifield, D., Foey, A., Apper, E. (2023) Modulation of Zebrafish (Danio rerio) Intestinal Mucosal Barrier Function Fed Different Postbiotics and a Probiotic from Lactobacilli. Microorganisms. 11(12):
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Jaronen, M., Wheeler, M.A., Quintana, F.J. (2022) Protocol for inducing inflammation and acute myelin degeneration in larval zebrafish. STAR protocols. 3:101134
- Sanmarco, L.M., Chao, C.C., Wang, Y.C., Kenison, J.E., Li, Z., Rone, J.M., Rejano-Gordillo, C.M., Polonio, C.M., Gutierrez-Vazquez, C., Piester, G., Plasencia, A., Li, L., Giovannoni, F., Lee, H.G., Faust Akl, C., Wheeler, M.A., Mascanfroni, I., Jaronen, M., Alsuwailm, M., Hewson, P., Yeste, A., Andersen, B.M., Franks, D.G., Huang, C.J., Ekwudo, M., Tjon, E.C., Rothhammer, V., Takenaka, M., de Lima, K.A., Linnerbauer, M., Guo, L., Covacu, R., Queva, H., Fonseca-Castro, P.H., Bladi, M.A., Cox, L.M., Hodgetts, K.J., Hahn, M.E., Mildner, A., Korzenik, J., Hauser, R., Snapper, S.B., Quintana, F.J. (2022) Identification of environmental factors that promote intestinal inflammation. Nature. 611(7937):801-809
- Cui, X., Du, C., Wan, S., Wu, D., Yan, L., Zhang, J., Li, J., Li, H., Yang, Z., Zhang, H., Zhang, J., Mu, H., Zhang, F., Peng, X., Liu, M., Hu, Y. (2021) Deficiency of Heat shock factor 4 promotes lens epithelial cell senescence through upregulating p21cip1 expression. Biochimica et biophysica acta. Molecular basis of disease. 1867(11):166233
- Helal, M., Yan, C., Gong, Z. (2021) Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model. Scientific Reports. 11:1372
- Li, Z., Liang, X., Liu, W., Zhao, Y., Yang, H., Li, W., Adamovsky, O., Martyniuk, C.J. (2020) Elucidating mechanisms of immunotoxicity by benzotriazole ultraviolet stabilizers in zebrafish (Danio rerio): Implication of the AHR-IL17/IL22 immune pathway. Environmental pollution (Barking, Essex : 1987). 262:114291
- Coronado, M., Solis, C.J., Hernandez, P.P., Feijóo, C.G. (2019) Soybean Meal-Induced Intestinal Inflammation in Zebrafish Is T Cell-Dependent and Has a Th17 Cytokine Profile. Frontiers in immunology. 10:610
- Wheeler, M.A., Jaronen, M., Covacu, R., Zandee, S.E.J., Scalisi, G., Rothhammer, V., Tjon, E.C., Chao, C.C., Kenison, J.E., Blain, M., Rao, V.T.S., Hewson, P., Barroso, A., Gutiérrez-Vázquez, C., Prat, A., Antel, J.P., Hauser, R., Quintana, F.J. (2019) Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation. Cell. 176(3):581-596.e18
- Willi, R., Castiglioni, S., Salgueiro Gonzalez, N., Furia, N., Mastroianni, S., Faltermann, S., Fent, K. (2019) Physiological and transcriptional effects of mixtures of environmental estrogens, androgens, progestins and glucocorticoids in zebrafish. Environmental science & technology. 54(2):1092-1101
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