ZFIN Image: Lai et al., 2020, Figure 1

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Figure Caption

Figure 1

Generation of dnmt3aa and dnmt3ab gene knockout (KO) zebrafish by using TALEN (transcription activator-like effector nuclease) genome-editing tool. (A) The location of TALEN right arm, spacer, and left arm on targeting zebrafish dnmt3aa and dnmt3ab genes are showed. (B) The Sanger sequencing dendrogram showed the sequence of wildtype, heterozygotes, and homozygotes of dnmt3aa (upper panel) and dnmt3ab (lower panel) mutants. (C) Three-dimension model predictions on the structure of wild type and Dnmt3aa and Dnmt3ab mutated proteins.

Acknowledgments

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