Activation of Hif1a signaling increases BEC number and impairs the proper formation of bile canaliculi. (A) Confocal projection images showing intrahepatic biliary network by Tp1:GFP expression in the liver (dotted lines) at 5 dpf. Boxed regions are enlarged. (B) Confocal projection images showing Tp1:H2B-mCherry expression (red; BEC nuclei) in the liver (dotted lines) at 5 dpf. Quantification of BEC number is shown. (C) Confocal projection images showing Abcb11 and Tp1:GFP expression in the liver (dotted lines) at 5 dpf. Arrowheads point to bile canaliculi. n indicates the number of larvae used for quantification. Scale bars: 50 μm; error bars: ± SD.
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