ZFIN Image: Zimmerli et al., 2020, Figure 3

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Figure Caption

Figure 3—figure supplement 1. Overlap of the high-confidence BCL9 and TBX3 peaks in developing murine limbs reveals the existence of BCL9 exclusive (one example displayed in the genomic tracks on the left) and TBX3 exclusive peaks (one example in the genomic track on the right).

The greatest group of BCL9 exclusive peaks, surprisingly, does not display high enrichment of TCF/LEF motifs, suggesting that a predominant genomic function of BCL9 is not related to Wnt/β-catenin signaling, as previously suggested by our work and that of others (Cantù et al., 2018; Cantù et al., 2017; Cantù et al., 2014; Jiang et al., 2020). On the other hand, BCL9 exclusive peaks (bottom-left table) show massive enrichment of Zinc Finger containing Sp/Krüppel-like-Factor (KLF) family of transcription factors. The TBX3 exclusive peaks (bottom-right table) display presence of TBX motifs – absent in the BCL9/TBX3 overlapping peaks. Genomic tracks are adapted for this figure from IGV Integrative Genomic Viewer (https://igv.org/). Motif analysis was performed with HOMER (http://homer.ucsd.edu/homer/).

Acknowledgments

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