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Figure 1—figure supplement 2.

ID: ZDB-IMAGE-200822-1
Source: Figures for Zimmerli et al., 2020

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Figure Caption

Figure 1—figure supplement 2. Intestinal epithelium-specific recombination of <italic>Pygo1/2 </italic>does not recapitulate the effects of deleting<italic>Bcl9/9l</italic>.

(A) Genetic recombination of Bcl9/9l and Pygo1/2 in tumors was monitored via qRT-PCR. Their expression is dramatically reduced (red bars) when compared to that in control mice (CTRL, black bars) confirming high recombination rate. (B) The intestinal epithelium-specific recombination of Pygo1/2 (in Pygo1/2-KO) does not recapitulate the effects of deleting Bcl9/9l (Bcl9/9l-KO) in dysplastic adenomas. The expression of genes associated with intestinal stem cell function was analyzed via quantitative RT-PCR, and the expression in the mutant cells (red) was compared to that in the control (CTRL, black).

Acknowledgments

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