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FIGURE 2
Alcian blue‐stained zebrafish embryos at 96 hpf displayed abnormal cranial development. A, Craniofacial atlas of the lateral view, the viscerocranium (ventral view) and the neurocranium (dorsal view): Bh, Basihyal; Cb, Ceratobranchial; Ch, Ceratohyal; Hm, Hyomandibula; Hs, Hyosymplectic; Ih, Interhyal; M, Meckel's; OP, Opercle (bone); Pq, Palatoquadrate; Ep, Ethmoid plate; Tr, Trabeculae; Pch, Parachordal of craniofacial structures. B‐O, Zebrafish treated with the following teratogens showed cranial malformations: B, Control, E3; C, DMSO, vehicle control; D, RA, retinoic acid; E, MTX, methotrexate; F, SA, salicylic acid; G, VPA, valproic acid; H, CAF, caffeine; I, WAF, warfarin; J, HU, hydroxyurea; K, DEX, dexamethasone; L, PHT, phenytoin; M, IM, imatinib; N, BA, boric acid; O, THA, thalidomide. P, The summary of craniofacial anomalies (Control: n = 45, DMSO: n = 40, RA: n = 35, MTX: n = 31, SA: n = 27, VPA: n = 36, CAF: n = 34, WAF: n = 32, HU: n = 28, DEX: n = 36, PHT: n = 35, IM: n = 27, BA: n = 33, THA: n = 39). Q, The body length analysis. Scale bars: 200 μm