Figure 4—figure supplement 1.

Figure 4—figure supplement 1.

(A) Schematic comparing zebrafish Prp1-3 proteins to human PrP. SP, signal peptide (dark grey); R, repetitive region (blue); HD, hydrophobic domain (yellow); N, glycosylation sites (black lines); GPI anchor residue (triangle); hydrophobic tail (coral). Aβ oligomer binding regions are shown in red. Breakpoints at repetitive regions indicate length variation. Adapted from Cotto et al., 2005. (B) Protein alignments of zebrafish Prp1, Prp2, and Prp3 proteins to human and mouse PrP proteins. Identical residues are marked in black, similar residues in grey. Aβ oligomer binding sites are indicated in red. The site of truncation mutations in prp1 and prp2 mutants are indicated with a triangle.