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Fig. 4
Biodistribution of fluorescently labeled HA-Cit and HA nanoparticles in zebrafish embryo. Biodistribution of fluorescently labeled HA-nanoparticles (in red) injected in casper embryos at 2 days post injection (2 dpi). At concentrations between 150–500 μg ml−1, all citrate-functionalized HA-Cit nanoparticles (top) were spread homogeneously throughout the embryos, whereas citrate-free HA nanoparticles accumulated near the injection site (bottom). HA nanoparticles are depicted in red, white arrowheads correspond to fluorescently labeled HA nanoparticles. Scale bar: 500 μm.
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