IMAGE

Fig. 3.

ID

ZDB-IMAGE-200703-28

Genes

myl7
nkx2-5

Publication

Sam et al., 2020 - Specificity, redundancy and dosage thresholds among gata4/5/6 genes during zebrafish cardiogenesis

All Figures

Figures for Sam et al., 2020

Image

Figure Caption

Fig. 3.

Gata5 and gata6 are redundant for cardiac specification. ISH was performed using offspring from a gata5^+/−, gata6^+/− in-cross with probes targeting either myocardial marker myl7 (left panels) or cardiac progenitor marker nkx2.5 (right panels). (A) gata5^−/−, gata6^−/− mutants exhibit a heartless phenotype and a complete loss of cardiac progenitors (indicated by arrows). Representative scale bar in WT panels: 0.1 mm. (B) Quantification of nkx2.5 staining shown in A. Error bars represent s.e.m. *P<0.05, ****P<0.0001. (C) Schematic showing that loss of gata5 and 6 disrupts the initial stages of heart development.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

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