ZFIN Image: Kuncha et al., 2018, Fig. 3

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Figure Caption

Fig. 3

ATD has a Gly-transPro motif in the active site, unlike a Gly-cisPro motif in DTD. a Comparison between Gly-transPro motif in MmATD and Gly-cisPro motif in PfDTD (PDB id: 4NBI) after structural superposition of the two proteins. b The comparison shown in a depicted from a different angle, highlighting the opposite orientation of Gly-Pro carbonyl oxygens of the two proteins. c Ramachandran plot of glycine and proline residues of the Gly-Pro motif of all the available crystal structures of DTD (blue) and ATD (red), highlighting the change of ~180° in the ψ torsion angle. d Interaction of the side chain of Arg7 with the Gly-cisPro motif of the same monomer in PfDTD (PDB id: 4NBI), and of the side chain of Arg151 with the Gly-transPro motif of the dimeric counterpart in MmATD. Residues from the dimeric counterpart are indicated by *

Acknowledgments

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