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Publication: Torraca et al., 2019 - Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence
All Figures: Figures for Torraca et al., 2019

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Figure Caption

Fig 3 <italic>S</italic>. <italic>sonnei</italic> virulence depends on its O-antigen.

A,B. Virulence of S. sonnei depends on its virulence plasmid. Survival curves (A) and Log₁₀-transformed CFU counts (B) of larvae injected in the HBV with S. sonnei -pSS (grey), Δmxid (blue) or WT (red) strains. Experiments are cumulative of 3 biological replicates. In B, full symbols represent live larvae and empty symbols represent larvae that at the plating timepoint had died within the last 16 hours. Statistics: Log-rank (Mantel-Cox) test (A); one-way ANOVA with Sidak’s correction on Log₁₀-transformed data (B); ns, non-significant; **p<0.0021; ****p<0.0001. See also S3H–S3K Fig for experiments at 32.5°C. C,D. Virulence of S. sonnei depends on its O-antigen. Survival curves (C) and Log₁₀-transformed CFU counts (D) of larvae injected in the HBV with S. sonnei ΔO-Ag (blue) or WT (red) strains. Experiments are cumulative of 3 biological replicates. In D, full symbols represent live larvae and empty symbols represent larvae that at the plating timepoint had died within the last 16 hours. Statistics: Log-rank (Mantel-Cox) test (C); unpaired t-test on Log₁₀-transformed data (D); ****p<0.0001. See also S3H–S3K Fig for experiments at 32.5°C.

Acknowledgments

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