ZFIN Image: Jamadagni et al., 2019, Fig. 4

Image

Figure Caption

Fig. 4

25-HC administration alters brain development in zebrafish: (A) Head size comparison between the treated and un-treated larvae at 2 dpf. Characterizing the larval brains at 2 dpf using Tg(huc:GFP) (B) and Tg(Isl1:GFP) (D) lines showed a decrease in the neuronal population and a defective development of the cranial nerves, in a dose dependent manner. (C) Larvae stained for acetylated α-tubulin at 2 dpf, showed reduced axon network clusters in the brain. All comparisons are performed with control, each trial has a n of 7 for control and treated over 4 trials, * represents a significance of p < 0.05, ** represents a significance of p < 0.01. Significance was determined using one-way ANOVA and all data are represented as Mean ± SEM. T: Telencephalon, MB: Midbrain, HB, Hindbrain. A, P represent anterior and posterior side of the head respectively.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Neurotoxicology