ZFIN Image: Swidergall et al., 2019, Figure 6.

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Figure Caption

Figure 6.

Candidalysin-induced immunopathology is required for virulence during hematogenously disseminated candidiasis. (A) Survival of immunocompetent mice after intravenous inoculation with 2 × 10⁵ yeast phase cells of the indicated strains of Candida albicans (n = 10). (B) Survival of leukopenic mice infected with 5 × 10⁴ wild-type or ece1Δ/Δ C albicans yeast. Statistical significance is indicated by **, P < .01 (wild-type vs ece1Δ/Δ) and ****, P < .0001 (ece1Δ/Δ+ECE1 vs ece1Δ/Δ+ECE1_Δ184–279) (Wilcoxon rank-sum test). (C) Fungal burden of the kidney, brain, spleen, and liver of leukopenic mice at 4 days postinfection after inoculation with 5 × 10⁴ wild-type or ece1Δ/Δ C albicans yeast. Results are median ± interquartile range with 6 mice per strain. Statistical significance is indicated by **, P < .01 (Mann-Whitney test). (D) Histopathology of the pelvis region (top, lower magnification; bottom, higher magnification) of the kidney of leukopenic mice after 4 days of infection with 5 × 10⁴C albicans cells of the indicated strains. Sections were stained with Gomori methenamine silver. Scale bars = 200 µm. CFU, colony-forming units.

Acknowledgments

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