The analysis of protein-metabolite interaction network. Whole network (A), the molecular functions of the selected proteins (B), and the first neighbor node of proteins linking to metabolites (C) indicate the interactions between protein and metabolites. Red triangle shows differential metabolites via metabonomics and blue circle shows their interacting proteins listed in the MBRole database. Yellow circle indicated interacting proteins with metabolites straightly correlated to hypoxia. Q9UPP1: PHF8; Q9NWT6: HIF1α; Q9GZT9: EGLN1; Q96KS0: EGLN2; Q9H6Z9: EGLN3; Q9NXG6: P4HTM; Q13131: PRKAA1; P47712: PLA2G4A.
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