IMAGE

Fig 6

ID

ZDB-IMAGE-191230-1325

Genes

emx2

Publication

Chen et al., 2019 - A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing

All Figures

Figures for Chen et al., 2019

Image

Figure Caption

Fig 6 The brain defect caused by SNPRE/SmE deficiency can be partially rescued by transcription factor EMX2.

(A), The expression of EMX2 gene is specifically disturbed in head of zebrafish after zSmE deficiency. (B), The zSmE deficiency leads to increased intron retention of EMX2. (C), The head defect caused by zSmE deficiency can be partially rescued by transcription factor EMX2. The morpholino and/or in vitro transcribed RNA is injected into embryo at 1-cell stage. Yellow line marked the region for quantification. (D), Quantification of zebrafish head size. Left, head size; middle, body length; right, head size normalized by body length. UN, un-injected; CO-MO, control morpholino; E-MO, SmE morpholino, EMX2, EMX2 gene in vitro transcript. The UN is normalized to 1. * P<0.05; ** P<0.01.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.