FIGURE 7

FIGURE 7

Buspirone increase the social preference for novelty in WT but not reln^–/–. (A) WT treated with saline spend equal time near the two groups of unfamiliar fish, whereas WT treated with buspirone switch preference and spend more time near the new group of unfamiliar fish. (B) Buspirone treatment does not completely rescue the impaired preference for social novelty of reln^–/– zebrafish (WT with saline p = 0.51; WT with buspirone p = 0.0039; reln^–/– with saline p < 0.0001; reln^–/– with buspirone p = 0.012). Three-way ANOVA followed by Sidak’s post hoc, genotype factor: F(1,56) = 0.2488, p = 0.62, stranger factor: F(1,56) = 2.11, p = 0.16, treatment factor: F(1,56) = 0.0124, p = 0.91, interaction genotype × stranger: F(1,56) = 40.28, p < 0.0001, interaction genotype × treatment: F(1,56) = 0.01879, p = 0.89, interaction stranger × treatment: F(1,56) = 3.362, p = 0.07, interaction stranger × genotype × treatment: F(1,56) = 0.0566, p = 0.81). n = 8 WT and n = 8 reln^–/–. ^∗p < 0.05, ^∗∗p < 0.01, ^****p < 0.0001. Mean ± SEM.