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Fig. 2
Human LC protein is expressed in the liver and secreted into circulation. The human λ LC protein was detected in the liver of transgenic fish by immunohistochemistry (red staining). Scale bar represents 30 µm (A). Human λ LC protein is detectable in the serum from transgenic fish at 2 yr of age (B). Quantification of serum-free LC (sFLC) levels using recombinant H7 protein (rLC) as a standard for quantification (***P < 0.001) (C). A concentration (125 µg/ml) comparable to patients with AL amyloidosis was detectable in the serum. Con, control; TG, transgenic.
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Full text @ Am. J. Physiol. Heart Circ. Physiol.