ZFIN Image: Sieber et al., 2019, Fig. 4

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Figure Caption

Fig. 4

Influence of PEG modifications on macrophage clearance in transgenic zebrafish. DiI labeled liposomes modified with the indicated PEG molecular weights were injected into the blood circulation of zebrafish 2 days post fertilization. Confocal images were acquired 3 and 24 h post injection (hpi). Colocalization analysis of green fluorescent macrophages (KAEDE) and DiI labeled liposomes was performed based on normalized overlap colocalization coefficients. Values are means ± SEM, n = 3. *P < 0.1 or **P < 0.05 (multiple comparison using ANOVA assuming equal variance and Bonferroni correction) as compared to 90 nm sized PEG350 liposomes.

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Reprinted from Nanomedicine : nanotechnology, biology, and medicine, 17, Sieber, S., Grossen, P., Uhl, P., Detampel, P., Mier, W., Witzigmann, D., Huwyler, J., Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo, 82-93, Copyright (2019) with permission from Elsevier. Full text @ Nanomedicine