ZFIN Image: Rueda et al., 2019, Fig. S5

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Figure Caption

Fig. S5

Schematic of the core Hippo signaling pathway and the consequence of YAP5SA expressed by the Yap5SA transgenic mouse (A) . Expression of the Yap5SA transgene in the adult mouse retina (B) . The transgene, indicated by GFP, is primarily expressed in the ONL. However, we observed mosaic expression among the MGs in the INL that was confirmed by SOX2 immunofluorescence (see inset from boxed region in B) . Upon tamoxifen injection (IP), YAP5SA (detected with an anti-FLAG antibody) is expressed in a subset of MGs that also express LacZ from the transgene’s IRES-LacZ cassette (C) . N = 3 per group. ONL = outer nuclear layer, INL = inner nuclear layer, GCL = ganglion cell layer

Acknowledgments

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