ZFIN Image: Oppel et al., 2019, Fig 1

Image

Figure Caption

Fig 1 CRISPR/Cas9-mediated knockout of <italic>atrx</italic> in zebrafish germline.

(A) The wildtype (WT) Atrx protein consists of 2013 amino acids (aa). Targeting of the atrx coding sequence with CRISPR/Cas9 resulted in truncation of Atrx before its functional domains and confers a loss of function; numbers indicate the underlying genetic alterations, e.g., +4 = insertion of 4 bases. (B)atrx-/- embryos show developmental abnormalities and die within 18 days post fertilization (dpf); sibling includes both atrx+/- and atrx+/+ embryos.

Figure Data

Phenotype details

Acknowledgments

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