ZFIN Image: Xie et al., 2019, Figure 3

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Figure Caption

Figure 3

(A,B) Aurone 5a induced cell cycle arrest. (C) Aurone 5a decreased tubulin polymerization. (D) Aurone 5a (5 µM) and colchicine (5 µM) inhibited tubulin polymerization in vitro in a similar fashion. (E) Competitive tubulin binding assay with colchicine in the presence of increasing concentrations of aurones 5a. (F–H) Aurone 5a treatment (6 h) inhibited microtubule structures and caused cell morphology change in PC-3 cells as shown in panels F, DMSO; G, 5a (1 µM); H, 5a (300 nM). Red immunofluorescence: α-tubulin; blue: DAPI.

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