ZFIN Image: Turner et al., 2019, Fig. 4

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Fig. 4

Suppressing cell death partially restores axonal/neuropil deficits in the tectum of slbp^ty77e mutants.

(A-B’) Lateral view of 26hpf wild type (A,B) and slbp^ty77e (A’,B’) heads and eyes stained with TUNEL. Apoptosis is prominent in the tectum (arrowhead) and dorsal hindbrain of the mutant (A’) but not within the eye (B’). The white lines outline the lens within which there is apoptosis in both the wildtype and mutant eyes. (C-C”) Lateral view of 72hpf untreated wildtpe (C), untreated slbp^ty77e (C’) and (C”) caspase inhibitor treated slbp^ty77e heads labelled with anti-acetylated tubulin (axons, green) and anti-SV2 (neuropil, red). Arrow shows aberrant retinal ganglion axons in the mutant eye. Abbreviations: AC, anterior commisure; E, eye; OT, optic tectum; T, telencephalon. Scale bar: (A-A’,C-C”) 100μm; (B-B’) 50μm.

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Acknowledgments

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