ZFIN Image: Paul et al., 2019, Fig. 2

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Figure Caption

Fig. 2

Human macrophages survive and interact with zebrafish stromal cells post-injection following brain injection. (a) Schematic of experimental design: primary monocytes were differentiated into macrophages before injection into the zebrafish brain at age 2 days post fertilization (dpf) and imaged at 1 and 2 days post injection (dpi). (b) 3D projections of whole head at 3 dpf (left) and 4 dpf (middle) showing distribution and survival of human primary macrophages (blue) injected into the hind brain of flk:mCherry (vessels-red) (top) and GFAP:GFP (astrocytes-green)/flk:mCherry (vessels-red) (bottom) zebrafish larvae. Boxes indicate positions of insets shown in right panels. Scales are indicated.

Acknowledgments

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