IMAGE

Fig. 4

ID

ZDB-IMAGE-180914-27

Antibodies

Ab1-mt-co1

Publication

Soma et al., 2018 - Elesclomol restores mitochondrial function in genetic models of copper deficiency

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Figures for Soma et al., 2018

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Figure Caption

Fig. 4

ES supplementation rescues pigmentation and the Cox1 deficiency of ctr1-KO zebrafish. (A–C) Clutches of embryos from a WT zebrafish and from a cross of a pair of ctr1^+/− heterozygous zebrafish were imaged at 48 hpf following treatment with and without 10 nM ES. Arrows in B indicate homozygous ctr1^−/− embryos with a pigmentation defect. (D) Mitochondria were isolated from 10-dpf WT zebrafish and homozygous ctr1^−/− zebrafish treated with and without 10 nM ES. Mitochondrial samples were subjected to SDS/PAGE and immunoblotted using the Complex IV-specific antibody anti-Cox1. The mitochondrial protein Atp5a was used as a loading control.

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA