ZFIN Image: Saydmohammed et al., 2018, Fig. 2

Image

Figure Caption

Fig. 2

In vivo whole organism chemical screen identified new hyperactivators of Fgf/Ras/Mapk signaling. (A) Representative fluorescence micrographs of Tg(dusp6:EGFP) embryos (30 hpf) treated at 24 hpf for 6 h. Top panel, original scan image; bottom panel, images with Cognition Network Technology (CNT) algorithm applied. All of the compounds listed above images were at 10 µM. (B) Confirmatory dose response assay using repurchased small molecules: ST06994, ST011282, and ST020101. Each data point represents an independent assessment of total green fluorescent protein (GFP) intensity in the head of zebrafish larvae (n = 8). Horizontal bars denote the mean ± S.D. from two or three independent experiments.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Molecules