ZFIN Image: Cosacak et al., 2017, Fig. 4

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Figure Caption

Fig. 4

(a) Immunohistochemistry (IHC) for TAU^P301L (red), GFP (green) and L-Plastin (white) on coronal sections of telencephalon of a 6 month-old sTg animal injected with PBS (a), sTg animal injected with A?42 (b), dTg animal injected with PBS (c), and dTg animal injected with A?42 (d). Insets below the panels show individual fluorescent channels for TAU^P301L (red), GFP (green) and L-Plastin (white). Columns 1?4 are single and merged images of the regions indicated in (a?d), respectively. (e) Quantification of the total number of ramified and round L-Plastin-positive cells in the telencephalon of sTg and dTg animals injected with PBS or A?42. (f?g) Immunohistochemistry for Interleukin-4 (red) on coronal sections of telencephalon of a 6-month old dTg animal injected with PBS (f) or with A?42 (g). (h) Relative change in the expression levels of il4 after A?42 injection compared to control injection. Medial ventricular regions are shown. DAPI (cyan) marks the nuclei. Values represent mean?�?s.e.m. *p?<?0.05, **p?<?0.01, ***p?<?0.005. Scale bars equal 50 ?m. n?=?6 fish and?>?30 histological sections for every staining. All animals are 6 months old.

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Acknowledgments

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