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Fig. S3
Long-lead burst neurons, HBO activity during secondary saccades and putative circuit architecture.
a, Sections of the velocity-tuned map (averaged over seven fish) showing the long-lead burst neurons located in two well-defined clusters in the dorsal region of rh 7. b, Example traces of these two clusters and associated gaze signals. c, Mean peri-saccadic signals. A systematic increase of activity is observed ~2-3 s before the ipsiversive saccade onset. d-e, Secondary saccades. d, Example traces of the left- and right-HBO activity and the gaze signal. When two successive saccades occur in the same direction (arrows), the active circuit displays a transient rebound. e, Mean peri-saccade signals of the HBO subnetworks for reorienting saccades (solid line) and secondary saccades (dashed line). The data are shown separately for ipsiversive (left) and contraversive (right) saccades. f, Scheme of a putative network architecture accounting for the HBO self-oscillatory dynamics and its interaction with the saccade generator circuit (burst cells). Each HBO subcircuit send inhibitory projections to the contralateral burst cells. It receives afferent excitatory inputs from ipsilateral burst neurons. g, Robustness of the HBO gaze-tuned characteristics. For each voxel of the right (blue) and left (red) HBO, we computed the fraction of ipsiversive saccades for which a significant post-saccadic increase in ?/ (larger than one standard deviation) is observed. The plot shows the PDF of this quantity for all the HBO voxels.