ZFIN Image: Yang et al., 2017, Fig. 4

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Fig. 4

Effects of serotonin level and HSC activation on kras^V12-induced carcinogenesis. Three-month-old adult zebrafish were treated with dox with or without serotonin, BW23C86, PCPA, and SB204741 for 7 days. (A) Gross morphology and H&E staining of liver sections. (B) Quantification of tumor size as a percentage of total abdominal area. (C) Quantification of tumor histology observed in the H&E-stained liver sections of these zebrafish is shown on the right (n > 8 in each group). (D and E) IF staining and quantification of (D) PCNA+ and (E) caspase 3+ cells in liver sections of these zebrafish (n > 8). *P < .05. Scale bars: (A) 3 mm for gross observation images and 20 μm for histology images, and (D and E) 20 μm. DAPI, 4',6-diamidino-2-phenylindole.

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Acknowledgments

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