ZFIN Image: Cai et al., 2016, Fig. S5

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Fig. S5

Effect of α-asarone and E. coli on the zebrafish embryonic development and resting microglial morphological dynamics

The Tg(Apo-E:eGFP) transgenic zebrafish embryos were treated with 0.3-3 µM α-asarone from 12 hours post fertilisation (hpf). The developmental status was examined at 5 days post fertilisation (dpf) and revealed no defect under α-asarone treatment (0.3-3µM) (A). Real-time live imaging of microglia cells from the optic tectum region of a 5-dpf larva (B) and captured morphological dynamics of resting microglia at 5-minute intervals. (C) Untreated, (D) 3µM α-asarone, (E) E. coli injection, (F) E. coli and α-asarone (3µM) co-treatment. The results showed no significant effect of E. coli and α-asarone to the resting microglial cell area, deformation speed and tip numbers (G).

Acknowledgments

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